Warfarin

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Warfarin [First Generation Anticoagulant Rodenticide]

Identity
Coumarin based compound.
Common name: warfarin, warfarine, coumadin, coumafene
IUPAC: 4-hydroxy-3-(3-oxo-l-phenylbutyl)-2H-1-benzopyran-2-one
Synonyms 4-Hydroxy-3-(3-oxo-1-phenylbutyl)coumarin; 3-(1′-Phenyl-2′-acetylethyl)-4-hydroxycoumarin
CAS Number: 81-81-2
Molecular Formula C19H16O4
Molecular Weight 308.33
CAS Registry Number 81-81-2

EINECS 201-377-6
Properties
Melting point 162-164 ºC
Boiling point 356 ºC
Water solubility Practically insoluble

TECHNICAL GRADE PRODUCT
Warfarin Technical 98% powerd

Warfarin sodium salt liquid 20% p/v
Technical Active Ingredient for bait formulation.

Marketed as a pesticide against rats and mice, and is still popular for this purpose, although more potent poisons such as brodifacoum have since been developed. A few years after its introduction, warfarin was found to be effective and relatively safe for preventing thrombosis and embolism (abnormal formation and migration of blood clots) in many disorders. It was approved for use as a medication in the early 1950s, and has remained popular ever since; warfarin is the most widely prescribed anticoagulant drug in North America. Despite its effectiveness, treatment with warfarin has several shortcomings. Many commonly used medications interact with warfarin, as do some foods and its activity has to be monitored by frequent blood testing for the international normalized ratio (INR) to ensure an adequate yet safe dose is taken.

Marketed as a pesticide against rats and mice, and is still popular for this purpose, although more potent poisons such as brodifacoum have since been developed. A few years after its introduction, warfarin was found to be effective and relatively safe for preventing thrombosis and embolism (abnormal formation and migration of blood clots) in many disorders. It was approved for use as a medication in the early 1950s, and has remained popular ever since; warfarin is the most widely prescribed anticoagulant drug in North America. Despite its effectiveness, treatment with warfarin has several shortcomings. Many commonly used medications interact with warfarin, as do some foods and its activity has to be monitored by frequent blood testing for the international normalized ratio (INR) to ensure an adequate yet safe dose is taken.

Warfarin is a synthetic derivative of coumarin, a chemical found naturally in many plants, notably woodruff (Galium odoratum, Rubiaceae), and at lower levels in licorice, lavender, and various other species. Warfarin and related coumarins decrease blood coagulation by inhibiting vitamin K epoxide reductase, an enzyme that recycles oxidated vitamin K to its reduced form after it has participated in the carboxylation of several blood coagulation proteins, mainly prothrombin and factor VII. For this reason, drugs in this class are also referred to as vitamin K antagonists

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